To optimize its performance, we reevaluated the model using only PGI < 70 ng/mL, PGI/PGII ratio ≥ 3.0, and CEA ≤ 5 μg/L (Positive‐Gastric‐GIST‐PG‐CEA) through 5‐fold cross‐validation. This evidence concerns the gene CEACAM5 and gastrointestinal stromal tumor.