Considering clinical practicality and risk scores, we established clinical threshold values (PGI < 70 ng/mL, PGI/PGII ratio ≥ 3.0, CEA ≤ 5 μg/L) to create a new binary variable combined with gender, ultimately developing the Gender‐Positive‐Gastric‐GIST‐PG‐CEA model. This evidence concerns the gene CEACAM5 and gastrointestinal stromal tumor.