This inconsistency might be due to the fact that, despite the higher T-cell infiltration in SC models, we observed a concurrent rise in pro-tumor T-cell subsets, including Tregs and IL17A+ γδ T cells, both of which are associated with immune suppression and resistance to ICBs (Lainé et al., 2021; You et al., 2024; Ma et al., 2014; Du et al., 2022). The gene discussed is IL17A; the disease is neoplasm.