As for SEM cells, bispecific CAR-iNKT cells were also more cytotoxic against CRISPRKMT2A-AFF1 ALL blasts than CAR T cells in vitro (supplemental Figure 4C), and similarly monospecific CD19 and CD133 CAR-iNKT cells were more cytotoxic against parental CD19+CD133+ SEM and RS4;11 cells and the CD19+CD133– KOPN8 KMT2Ar cells when compared with CAR T-cell counterparts (supplemental Figure 4C). The gene discussed is PROM1; the disease is acute lymphoblastic leukemia.