CAR-iNKT cells and to a lesser degree CAR T cells that had been preexposed to CAR target–expressing leukemia cells displayed higher cytotoxicity against CAR target–negative SEM cells than CAR-iNKT cells that had been preexposed to leukemia cells lacking expression of the CAR targets (Figure 5I), and this effect was attenuated by NKG2D blockade. Here, KLRK1 is linked to leukemia.