2014; Mennink et al. 2022; Tang et al. 2024). There are also cross‐sectional studies on tinnitus and healthy people with (near) normal hearing and no signs of depression or anxiety, which found that the concentration of IL‐10 and IFN‐γ cytokines in tinnitus participants was lower than that in the control group (Mennink et al. 2024). Recent studies have also found that the TLR4/NF‐κB/NLRP3 protein/caspase‐1/IL‐1β signaling pathway is essential in neuroinflammation in noise‐induced tinnitus mice (Luo et al. 2024). The gene discussed is TLR4; the disease is Tinnitus.