hiPSC from two human donors (MF002B2 and MF007C1) diagnosed with T2D were subjected to single‐base genome editing of the MTNR1B (rs10830963) risk allele (G/G), using CRISPR/Cas9 (See Table 1A–C for patient information and Figure 1A,B for work‐flow of skin biopsy procurements for generation of hiPSC with genome editing and subsequent differentiation to β‐cells). The gene discussed is MTNR1B; the disease is type 2 diabetes mellitus.