As shown in Fig. 2, the genetically predicted variants associated with LDL-C reduction in NPC1L1 (OR = 1.943 [95% CI, 1.116–3.383]; P = .018), LDLR (OR = 1.279 [95% CI, 1.107–1.477]; P < .001), and TG reduction in APOC3 (OR = 1.174 [95% CI, 1.054–1.307]; P = .003) were associated with an increased risk of SNHL. Here, NPC1L1 is linked to sensorineural hearing loss disorder.