HMGCR and sensorineural hearing loss disorder: Previous observational studies have suggested an association between lipid levels and SNHL, indicating that elevated levels of low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG) may exacerbate SNHL.[8,9] Statins are a commonly used class of lipid-lowering drugs that reduce circulating LDL-C levels by targeting 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR).