NPC1L1 and sensorineural hearing loss disorder: However, genetic proxies for lowering low-density lipoprotein cholesterol, specifically variants in NPC1L1 (OR = 1.943 [95% CI 1.116–3.383]; P = .018) and LDL receptor (LDLR) (OR = 1.279 [95% CI 1.107–1.477]; P < .001), were associated with an increased risk of SNHL.