Additionally, there have been reports of a familial genetic tendency for the disease, and its genetic and pathogenic mechanisms may be related to mutations in the HMGI-C gene.[15] Kume et al[16] reported cases of achondroplasia complicated by pelvic lipomatosis, and since achondroplasia is a congenital genetic disorder, it is speculated that pelvic lipomatosis may be related to congenital or genetic factors. The gene discussed is HMGA2; the disease is pelvic lipomatosis.