IL-1β promotes cancer cell migration, invasion, and aggressiveness while also inducing immunosuppression, local tumor growth, and angiogenesis.[55] IL-33 might function as an anti-tumorigenic and pro-tumorigenic cytokine.[56] Depending on the context, IL-6 can prevent or promote cancer development.[57] IL-18 is a pro-inflammatory cytokine that is associated with tumor mobility, invasion, and metastasis. This evidence concerns the gene IL33 and neoplasm.