E2F1 and cancer: FOXC1 is involved in cancer cell proliferation, progression, differentiation, and metastasis in different cancer types, such as basal breast cancer, and hepatocellular carcinoma.[45]PRRX2 is linked with increased invasion and migration in mammary epithelial cells and is linked to unfavorable outcomes in breast cancer.[46] In TME, STAT3 is overexpressed in both malignant and non-cancerous cells and inhibits the expression of immune activation.[47]E2F1 promotes cancer metastasis.[48] This study identified various miRNAs associated with hub genes.