TNF and cardiovascular disorder: Tanshinone IIA, a lipophilic component of Danshen, effectively exerts anti-inflammatory effects by blocking the upregulation of pro-inflammatory mediators such as tumor necrosis factor-alpha and interleukins.[10] Maione F et al[11] demonstrated that tanshinone IIA inhibits rat platelet aggregation and activation through the ERK-2 signaling pathway, suggesting its efficacy in improving blood viscosity and microcirculation, and in preventing cardiovascular diseases.