Serum IL-6 concentration in psoriasis patients is positively correlated with blood sedimentation, lesion area, and PASI index of psoriasis patients, and psoriasis patients with high levels of IL-6 are more prone to joint damage, which can be used as an indicator of psoriasis inflammatory activity, and there is a synergistic effect between IL-6 and AKT1. The gene discussed is AKT1; the disease is psoriasis.