VDR and breast carcinoma: Moreover, high VDR expression in breast carcinomas has been shown to be associated with better prognosis and survival.[11] It has been stated that VDR blocks mitogenic activity driven by estrogen and also has an inverse relationship with breast carcinoma invasiveness.[12,13] It has been said that activation of VDR is effective in both tamoxifen treatment and resistance development to this drug in ER-positive patients.