The above phenomena confirm that the intrinsic characteristics of tumor cells, including genetic changes, epigenetic changes, metabolic reprogramming, and signal release, are the key determinants of TME shaping.[24] Changes in the intrinsic characteristics of cancer cells can alter secreted substances, cell surface receptors, or ligands; affect the cargo load and abundance of extracellular vesicles ; and alter the use of nutrients, leading to a wide range of changes in the tumor immune environment. This evidence concerns the gene CD177 and cancer.