PDCD1LG2 and neoplasm: As Figure 8 shows, the mutation, methylation, or related transcription factors of YRDC could change YRDC expression; Then high YRDC expression upregulated tumor cell proliferation and changed the immune cell infiltration in tumors by affecting the expression of cytokines or immune proteins such as IFN‐α, PD‐L1/PD‐L2, etc. Furthermore, the positive relationships between YRDC and immunotherapy efficacy and several anticancer drugs sensitivity were confirmed.