YRDC and neoplasm: According to our results, 450 CRISPR Screens studies in 19 tumors (including LUAD, COAD, OV, BRCA, GBM, LGG, SKCM, PAAD, ESCA, STAD, BLCA, UCSE, LUSC, KIRC, LIHC, HNSC, PRAD, THCA, CHOL and CESC) identified YRDC as an essential gene for tumor cell proliferation (Figure 5B).