Log10-transformed normalized abundance of SERPINC1 (ALS: -0.12, IQR: -0.48, 0.13; controls: 0.08, IQR: -0.18, 0.29; padj = 0.037) and HP (ALS: 0.04, IQR: -0.21, 0.66; controls: 0.54, IQR: 0, 0.91; padj = 0.050) was significantly lower in ALS compared to controls. This evidence concerns the gene SERPINC1 and amyotrophic lateral sclerosis.