We also found that the expression of Lama5 and Col4a2 in the 10-month-old mice was significantly reduced, indicating a gradual impairment in the basement membrane structure, an increase in the BBB permeability, and the probable entry of toxic substances and immune cells in the blood into the brain tissue, which ultimately results in aggravated inflammation and nerve cell damage and accelerates the progression of neurological diseases and aging. This evidence concerns the gene COL4A2 and nervous system disorder.