SLC2A1 and Alzheimer disease: Our results also showed that the expression of Glut1 in the brain microvessels decreased in both male and female mice with the advancing age, reflecting the reduced transport of glucose into the brain, which is also one of the early pathological characteristics of AD [60], as the reduction of Glut1 can exacerbate the vascular and neurological dysfunction and degeneration in AD pathology [14].