Data presented as number (percentage); * indicated median (1st to 3rd quartile range); AQP4-IgG: Antibodies to aquaporin 4; CIS: Clinically isolated syndrome; NMOSD: Neuromyelitis optica spectrum disorder; ADEM: Acute disseminated encephalomyelitis; SLE: Systemic lupus erythematosus; SDAVF: Spinal dural arteriovenous fistulas. This evidence concerns the gene AQP4 and in situ carcinoma.