Several factors contribute to the development of hypoalbuminemia in PLWHIV, such as increased albumin leakage during inflammatory response disease due to chronic inflammation, increased transcapillary escape of albumin due to impaired barrier function of the endothelium caused by the HIV-1 Tat1 protein, HIV infection-induced liver damage, diminished microbial clearance, impaired or decreased protein synthesis that enhances inflammation and reduced food intake due to decreased appetite [3–5]. This evidence concerns the gene ALB and HIV infectious disease.