GSDMD and myocardial infarction: Moreover, a shortterm diet rich in palmitic acid strongly elevates Spalmitoylation of GSDMD at Cys192 in the myocardium, exacerbating pyroptosis and infarct size after myocardial infarction; the depalmitoylation antagonist disulfiram reverses these injuries and improves cardiac function by preventing palmitoylation at this site [156].