Finally, 1,734 subjects, including 1,065 HCs (age = 45 [31, 54], median [interquartile range, IQR] female percentage = 566/1,065), 278 AQP4 + NMOSD (age = 43 [31, 53] years; female percentage = 256/278) and 391 MS (age = 34 [27, 42] years, female percentage = 264/391) were included in this study (Table 1). The gene discussed is AQP4; the disease is myeloid sarcoma.