In AQP4 + NMOSD, NMOSD-CE showed relatively reduced EDSS progression (Hazard Ratio [HR] = 0.11, 95%CI [0.01, 0.99], p = 0.049) and relapse (HR = 0.13 [0.03, 0.69], p = 0.017). This evidence concerns the gene AQP4 and cholesteryl ester measurement.