Many studies agree upon miR-146a’s direct interaction with target mRNAs such as those encoding IRAK1, IL receptor-associated kinase 2 (IRAK2) and TNF receptor-associated factor 6 (TRAF6), members of the NF-κB signalling cascade, directly via antisense oligos targeting miR-146 or indirectly via cell-derived exosomes with miR-146a-5p cargo targeting the diabetes-related wound healing impairments [7, 27, 28]. Here, TRAF6 is linked to diabetes mellitus.