This requires validation in larger cohorts, and further investigation into which T cell subtypes play a key role, but may be due to the presence of regulatory T cells (Tregs), including OX40 + T regs, in the infiltrate, which has been reported previously by our group to suppress tumoral effector T cells and associate with cSCC metastases33. This evidence concerns the gene TNFRSF4 and skin squamous cell carcinoma.