SENP3 and acute lymphoblastic leukemia: In particular, the transcriptional status of TBX21 further revealed the specific role of SENP3 in the chemosensitization of ALL cells to Ara-C via STAT6 targeting (Fig. 5E and Supplementary Fig. 3E), hence supporting the notion that Ara-C-induced SENP3 confers a feedback resistance upon ALL cells at least to some extent.