In this respect, we further found that the anticancer drug monomer Tanshinone I (TS1), a natural o-quinone [12], synergized with Ara-C to induce apoptosis in ALL cells by reducing STAT6 levels; this synergistic effect was directly proportional to the immediate status of TBX21 transcription. The gene discussed is STAT6; the disease is acute lymphoblastic leukemia.