TBX21 and acute lymphoblastic leukemia: Moreover, TBX21 mRNA levels were directly proportional to the synergistic effect of TS1 with Ara-C (Fig. 2G and Supplementary Fig. 2F), which not only echoes the above RNA-Seq data but also establishes the specific role of TBX21 in tg-STAT6-enhanced chemosensitization of ALL cells to Ara-C.