We also explored the molecular mechanism underlying this Ara-C potentiation: tg-STAT6-enhanced chemosensitization of ALL cells to Ara-C was positively correlated with the transcription of TBX21, whose coded protein T-bet serves as a bridge between innate and adaptive immunities by regulating a transcriptional network of genetic programs [27]. Here, STAT6 is linked to acute lymphoblastic leukemia.