The observed correlation between younger current age and the risk of early insulin initiation aligns with the guidelines’ age consideration in targeted HbA1c levels and the existing literature on the natural progression of T2DM.40 Individuals diagnosed at a younger age, such as in their early 40s, often experience a more aggressive form of diabetes, leading to greater beta-cell dysfunction and increased insulin resistance over time.41,42 Additionally, challenges in changing longstanding dietary habits can exacerbate the condition. This evidence concerns the gene INS and type 2 diabetes mellitus.