Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterised by insulin resistance and relative insulin deficiency.1 As the disease progresses, managing T2DM often requires a comprehensive approach that includes lifestyle changes, oral hypoglycaemic agents, and potentially daily insulin therapy.2 Timely intensification of medication is crucial to maintain glycaemic control and prevent or delay complications.3,4. This evidence concerns the gene INS and Insulin resistance.