This finding suggests CD4+ T cells could potentially also contribute to antitumoral T-cell responses in neuroblastoma, similar to what was previously reported for several adult solid tumors (Oja et al, 2017; Oh et al, 2020; Cachot et al, 2021; Nicolet et al, 2021; Kruse et al, 2023). Here, CD4 is linked to neuroblastoma.