Coculture of TILs with autologous tumor digest resulted in significantly increased CD137 expression in all T-cell subsets when compared to medium control (Fig 3B; CD8+ T cells: P = 0.02; CD4+ T cells: P = 0.05; γδ T cells: P = 0.02). The gene discussed is TNFRSF9; the disease is neoplasm.