Furthermore, using the Catalogue Of Somatic Mutations In Cancer (COSMIC) database (https://cancer.sanger.ac.uk/cosmic), we found one somatic mutation each in the PP1-binding motif (R1289S) and the calcineurin-binding motif (L1142P), and also two somatic TSC2(E/K) mutations of the PP2A-B56–binding motif ([L/M/F/I]-x-x-[I/L/V]-x-E-x) in three clinical cases: E366K in rectal adenocarcinoma (https://cancer.sanger.ac.uk/cosmic/mutation/overview?id=102914022) and ovarian carcinoma (Cheasley et al, 2019), and E1583K in skin carcinoma (Starrett et al, 2020) (Fig 5F and Supplemental Data 3). This evidence concerns the gene TSC2 and skin carcinoma.