Furthermore, we discovered several somatic mutations that cluster in PP2A-B56 binding sites of TSC2 among previously reported TSC2 mutations: the L361P mutation in a tuberous sclerosis case (Dabora et al, 2001), E366K mutations in rectal adenocarcinoma (https://cancer.sanger.ac.uk/cosmic/mutation/overview?id=102914022) and ovarian carcinoma (Cheasley et al, 2019), and the E1583K mutation in skin carcinoma (Starrett et al, 2020). This evidence concerns the gene TSC2 and rectum adenocarcinoma.