Moreover, the regulatory role of A20, but not CYLD was significantly related to Dox-treated macrophage maturation and apoptosis in cHL patients, as elevated expressions of the apoptotic markers, costimulatory molecule CD40 and levels of IL-1β in macrophages when exposed to Dox in the absence of A20, which was documented for the first time. The gene discussed is CD40; the disease is classic Hodgkin lymphoma.