Expressions of signaling molecules, including mTOR, mitogen activated protein kinase (MAPK)p38, extracellular signal-regulated kinase (ERK), Wnt and AKT were assessed in Vinc/Dox-treated macrophages to determine the mechanism involved in A20-sensitive macrophage activation in cHL patients. Here, TNFAIP3 is linked to classic Hodgkin lymphoma.