↓ Metabolic and reproductive disturbances, including estrous cycle irregularities, obesity, ovulation disorders, serum testosterone, lipopolysaccharide levels, IL-6, TNF-α, NLRP3, pyroptosis, cleaved-caspase-1, GSDMD, IL-1β, IL-18. The gene discussed is CASP1; the disease is obesity due to melanocortin 4 receptor deficiency.