Regarding the regulatory pathway of ERK extracellular kinase1/2 and CREB in relation to neuroprotective effects, the amounts of proteins related to the neuroprotective pathway ERK1/2 were not significantly different between the groups, but CREB values in the CTID group increased by 67% compared to the stroke group and 48.9% compared to the CTII group. The gene discussed is MAPK3; the disease is stroke disorder.