In this regard, Li et al. investigated the effect of high and low-intensity exercise training after stroke induction in 3, 14, and 28 days, in which protein factors such as tau, GAP-43, PSD- 95 evaluated SYN as synaptic proteins and HI1α, BDNF, NGF, TRKB, and CREB proteins as neurogenic proteins in the hippocampus. This evidence concerns the gene CREB1 and stroke disorder.