In this regard, the effect of different intensities of exercise after a stroke has been investigated, the high-intensity endurance training protocol includes running on a treadmill at a speed of 30 m/min for 30 min and moderate-intensity endurance exercise, ten minutes at a speed of 5 m/min, ten minutes 9 m/min, and ten minutes 12 m/min, which the results showed performing endurance exercises significantly reduced the infarct volume and increased neuroplasticity and angiogenesis markers including HIF-1α, BDNF, TrkB, and CREB (14). This evidence concerns the gene CREB1 and Stroke.