Angiogenic factors in the present research in the continuous training group had a significant increase compared to the control group, and the values of VEGF in the CTID group increased by 49% compared to the CTII group and 52.7% compared to the stroke group, while the values VEGF-R2 protein increased by 56% in the CTII group compared to the CTID and 109% compared to the stroke group. The gene discussed is VEGFA; the disease is Stroke.