Therefore, in this study, we evaluated the effects of two types of endurance training with increasing intensity and duration on the effectiveness of irisin in modulating apoptotic factors such as ERK1/2/P90RSK/CREB signaling, neurogenic and angiogenic factors such as BDNF/TRKB/CREB, and VEGF/VEGF-R2, during the post-stroke rehabilitation period in td-MCAO stroke model rats. This evidence concerns the gene MAPK3 and stroke disorder.