The reduction of stroke volume and changes in neurotrophic factors aligned with, a study that investigated the effects of different exercise intensities after ischemic stroke which stroke volume was decreased after short time of training sessions and also reported that the levels of BDNF, TrKB, and NGF in the training groups increased significantly compared to the control group during 3 and 14 days after stroke (5). The gene discussed is NTRK2; the disease is stroke disorder.