VEGFA and ischemic stroke: On the other hand, Ischemic stroke occurs when the blood vessels that supply oxygen and fuel to the nerve cells are blocked, which then causes nerve cell death in the stroke area due to acidosis and hypoxia (16), which is why the amount of blood supply to the nerve cells in the penumbra area in post-stroke rehabilitation it is very important that changes in the expression of Vascular Endothelial Growth Factor (VEGF) protein and its receptor (VEGF-R2) inhibit apoptotic catabolic factors and increase neurogenesis factors in stroke recovery (17).