,53 In this context, miR-486, which has not been identified to be regulated by IL-6 in sensory neurons,10 is a pleiotropic miRNA that can act as an oncomiR as well as a tumor-suppressor,54 and is associated with skeletal muscle development,55 coronary and heart disease, cystic fibrosis54 as well as neurogenesis.54 This evidence concerns the gene IL6 and heart disorder.