ZMYND11 and myotonic dystrophy type 1: ,75 Other targets of miR-409-3p, such as ZMYND11,76KDM2A,77,78 and PHF19,79,80,81 are involved in chromatin remodeling and histone modification, which may impact the epigenetic regulation of the DMPK gene or alter the expression of neighboring genes, contributing to the complexity of DM1 symptoms.