Among the differentially expressed genes regulated by probiotics, the conserved domain LBH of LBHD1 is associated with a variety of diseases including nasopharyngeal carcinoma, rheumatoid arthritis, congenital heart disease, and human breast cancer, and is a transcriptional activator in the mitogen-activated protein kinase (MAPK) signaling pathway (Dong et al., 2019). This evidence concerns the gene LBHD1 and congenital heart disease.