Coroglaucigenin (CGN), a natural product isolated from calotropis gigantean, exhibited an activity of HSP90 inhibitor, which disrupted the association of HSP90 with both CDK4 and Akt, leading to CDK4 degradation and Akt dephosphorylation, eventually resulting in senescence and autophagy in CRC cells (127). The gene discussed is CDK4; the disease is colorectal carcinoma.