However, the frequency of the LPTS/PinX1 loss often occurred in most cancer tissues, including the colorectum (COAD), head and neck (HNSC), cervical (CESC), liver (LIHC), lung (LUAD), breast (BRCA), pancreas (PAAD) and gastric (STAD) cancer tissues (data from The Cancer Genomic Atlas, https://portal.gdc.cancer.gov/analysis_page?app=CohortBuilder&tab=general) (Figure 1A). The gene discussed is PINX1; the disease is cancer.