In degenerative conditions such as AD, ALS, Huntington's disease (HD), and Parkinson's disease (PD), overactivation of components like C1q, C3, and C5a drives aberrant synaptic pruning, fuels microglia-mediated neuroinflammation, and in some cases induces dopaminergic neuron loss. Here, C3 is linked to amyotrophic lateral sclerosis.