More specifically, we determined that FBXO7 silencing induces CIN in both non-malignant and malignant human colonic epithelial cells, and that CRISPR-Cas9-generated FBXO7+/− and FBXO7−/− clones exhibit dynamic CIN phenotypes and cellular transformation over time.11 Here, FBXO7 is linked to cervical squamous intraepithelial neoplasia.