However, the determination of which of the numerous molecular events that are required to cause the switch from apoptotic signaling to necroptosis, such as internalization of death receptor complex II, proper de-ubiquitination, and phosphorylation of RIP kinases, and caspase-8 inactivation by, for example, c-FLIP,34 which was causative during rVSV-activated necroptosis in NSCLC cells, was not resolved in our work. Here, CASP8 is linked to non-small cell lung carcinoma.