In a rat model of pulmonary hypertension, it downregulates SERCA2a expression while upregulating its inhibitory protein PLB (phospholamban), resulting in reduced sarcoplasmic reticulum calcium uptake capacity and impaired left ventricular contractile function (Wang et al., 2017; Figure 2, Loop 4). The gene discussed is PLN; the disease is pulmonary arterial hypertension.