Reduced serum Cp levels, or hypoceruloplasminemia, have been observed in several neurodegenerative disorders, including Wilson’s disease, Alzheimer’s disease, and Parkinson’s disease, where they are often associated with abnormal iron metabolism and excessive iron deposition in specific brain regions, leading to neuronal damage and cognitive decline (13, 14). The gene discussed is CP; the disease is early-onset autosomal dominant Alzheimer disease.