Research has shown that EA stimulation on HT7 alleviates anxiety and negative emotions induced by repeated alcohol administration by reducing plasma corticosterone levels, increasing amygdala expression of mature brain-derived neurotrophic factor and phosphorylated TrkB, and decreasing corticotropin-releasing hormone levels in the paraventricular nucleus, thereby modulating stress-related pathways (94). This evidence concerns the gene NTRK2 and Anxiety.