ATRX and microcytic anemia: When considering comparisons between other ATRX mutations, p.Arg2465Cys shows some distinct patterns: increased incidence of microcytic anemia without detectable HbH inclusions (40% vs. 10-15% overall), slightly greater renal abnormality rate (15-20% vs. 10-15% overall), and a lower proportion of patients with seizures (25-30% vs. 30-35% overall) [12].