When morphology is equivocal, immunohistochemistry (p16, p53, Ki‐67) and emerging molecular panels can aid differentiation: aberrant p16/p53 with a diffuse Ki‐67 pattern favors cSCC, whereas solitary keratoacanthoma more often shows a peripheral, graded Ki‐67 pattern [5]. This evidence concerns the gene CDKN2A and skin squamous cell carcinoma.