5-ASA: 5-Aminosalicylic Acid, Anti-TNF: Anti-Tumour Necrosis Factor, IV: Intravenous, JAK inhibitors: Janus Kinase Inhibitors, RCT: Randomized Controlled Trial, SC: Subcutaneous, UC: Ulcerative Colitis, UNIFI: Ustekinumab as Induction and Maintenance Therapy for Ulcerative Colitis, UST: Ustekinumab. The gene discussed is TNF; the disease is ulcerative colitis.