Model 1: adjusted for age, sex; Model 2: further adjusted for further adjusted for BMI, origin, smoking status, alcohol consumption, SBP, DBP, HDLc, LDLc, anti-hypertension medication, lipid-lowering medication, history of diabetes, and eGFR.PICP: C-terminal propeptide of procollagen type I; hsTnT: high-sensitivity troponin T; hsCRP: high-sensitivity C-reactive protein; 3-NT: 3-nitrotyrosine; NT-proBNP: N-terminal propeptide of B-type natriuretic peptide. The gene discussed is NPPB; the disease is diabetes mellitus.