MTOR and melanoma: Among the 31 significantly enriched pathways in the WT vs. HB comparison, those associated with high-altitude adaptation included mTOR signaling (oas04150), melanoma (oas05218), fatty acid metabolism (oas01212), Wnt signaling (oas04310), cancer (oas05200), and metabolic (oas01100) (Figure 4F; Supplementary Table S9).