In human bone marrow-derived MSCs, the half-maximal effective concentration (EC50) values of AKDS0001 for increasing intracellular cAMP were similar between the two types of donors (patients with hip fracture and patients with ONFH) and the healthy controls (Supplementary Table S3), suggesting that the EP4 agonistic activity of AKDS001 was not decreased in ONFH patients with a history of steroid use. The gene discussed is PTGER4; the disease is hip fracture.