estimated that 93% of high grade glioma cases expressed at least one of IL13Rα2, HER2 or EGFR antigens (72% at least two) (99).This makes multitargeting as a clear path forward for enhancing therapeutic efficacy, with approaches targeting multiple pathways simultaneously already being evaluated in both clinical and preclinical trials (26, 92, 100–104). Here, IL13RA2 is linked to glioma.