CACNA1D and type 2 diabetes mellitus: This intriguing finding could imply several possibilities: these genes might be downregulated in specific pro-inflammatory macrophage populations prevalent in T2D islets; their decreased expression could be part of a disrupted regulatory mechanism within macrophages in the T2D microenvironment; or it may reflect a shift in macrophage subpopulations, where those with higher expression of CACNA1D and CALM1 are less abundant.