TDP2 and type 2 diabetes mellitus: On the other hand, several hub genes identified in our study—namely CLDN10 (claudin 10), NUP214 (nucleoporin 214), TDP2 (tyrosyl-DNA phosphodiesterase 2), and UNC93B1 (unc-93 homolog B1)—have not been previously extensively associated with T2D.