In plasma samples, people living with HIV/AIDS (PLWHA) showed significantly higher levels of HlyA-specific antibodies across multiple antibody classes, including IgG1 (log10 median: HIV-negative = 4.27, HIV-positive = 4.50, p.adj < 0.05), IgG3 (log10 median: HIV-negative = 3.37, HIV-positive = 4.17, p.adj < 0.001), and total IgG (log10 median: HIV-negative = 4.62, HIV-positive = 4.96, p.adj < 0.01). Here, IGHG3 is linked to AIDS.