Response to treatment was defined as endoscopic- (≥50% drop in simple endoscopic score for Crohn’s Disease (SES-CD)) in combination with biochemical (≥50% reduction in C-reactive protein (CRP) and fecal calprotectin (FCP) or an absolute CRP<5.0 μg/g and FCP<250 μg/g) and/or clinical response (≥3 point drop in Harvey-Bradshaw Index (HBI)) compared to the start of treatment. The gene discussed is CRP; the disease is Crohn disease.