Conversely, the C1 cluster was mainly associated with pathways affecting the structure and function of the cardiovascular system and cell signaling, such as glycoprotein complex, regulation of cell communication by electrical coupling involved in cardiac conduction, dilated cardiomyopathy, hypertrophic cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, vascular smooth muscle contraction, the TGF-beta signaling pathway, and the Wnt signaling pathway (Figures 4J, K). Here, ART4 is linked to arrhythmogenic right ventricular cardiomyopathy.