This situation is particularly pronounced in obese patients, where overnutrition stimulates adipogenesis, creating an imbalance in the body’s microenvironment, inducing progressive hypertrophy of adipocytes, stimulating the ER to synthesize more proteins for the formation of lipid droplets, and altering the flow and thickness of ER membranes via the ER sensors IRE1α and PERK, which lead directly to ERS (72). This evidence concerns the gene ERN1 and overnutrition.